Gluthanol™.Cartilage nutrition,from inside the cell.
A four-part blend of N-acetylcysteine, L-glycine, L-glutamine and alpha-lipoic acid, built to supply the raw materials cartilage cells make glutathione from.
Most joint nutrition feeds the matrix. Gluthanol™ supplies the cell.
Cartilage is a matrix of collagen and cushioning gel, kept by cells that make up about 2% of it and live without a blood supply Sophia Fox 2009. Those cells defend themselves with glutathione, and how well they survive stress tracks how much of it they have Del Carlo 2003.
Gluthanol™ is built around that defence. It contains no glutathione. It supplies what the cell makes glutathione from, so the cell can make its own.
Four parts, one pathway.
N-acetylcysteine supplies cysteine
Cysteine supply is one of the two key controls on glutathione synthesis. In cartilage cells, NAC's protection depended on glutathione being made.
Lu 2013 · Nakagawa 2010L-glycine finishes the molecule
The third building block, and the most common amino acid in collagen. Extra glycine raised type II collagen production by cartilage cells.
de Paz-Lugo 2018L-glutamine supplies glutamate
Cartilage cells turn glutamine into glutamate, and glutathione made from it helps them survive without a blood supply.
Stegen 2020Alpha-lipoic acid helps the cell use cysteine
Reduced inside the cell, it turns cystine into cysteine the cell can take up, raising glutathione mainly where it was low.
Han 1997
Soothe. Nourish. Lubricate. Three technologies, one joint.
Gluthanol™ is the Nourish technology. MMP13 Cartilage Technology™ is the Soothe technology, built around the enzyme that cuts cartilage collagen. The Lubricate technology looks after the joint fluid.
They meet in the same cell. In human cartilage cells, oxidative stress is one of the signals that lowers SOX9 and switches MMP13 on Rong 2019, and in rats NAC held MMP13 back Kaneko 2019.
The evidence, rung by rung.
Every ingredient
NAC, glycine, glutamine and alpha-lipoic acid each have cartilage-cell or animal research on glutathione, cell survival or cartilage breakdown.
Glycine and NAC
Glycine plus NAC (GlyNAC) raised glutathione in older adults in placebo-controlled and open trials, measured in blood. Those are the trials' results, not Gluthanol's.
The full blend
The Gluthanol™ blend itself has not yet been tested in a published study.
Every ingredient, every study.
What each part is, what job it does and the papers behind it.